Transcription factor CREB and its extracellular signals
| PAG Title | Transcription factor CREB and its extracellular signals |
| PAG ID | WIG000294 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,639 |
| Information Content | Rich |
| Other IDs | M9070 |
| Base PAG ID | WIG000294 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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